Tomato I2 Immune Receptor Can Be Engineered to Confer Partial Resistance to the Oomycete Phytophthora infestans in Addition to the Fungus Fusarium oxysporum.
Identifieur interne : 000D49 ( Main/Exploration ); précédent : 000D48; suivant : 000D50Tomato I2 Immune Receptor Can Be Engineered to Confer Partial Resistance to the Oomycete Phytophthora infestans in Addition to the Fungus Fusarium oxysporum.
Auteurs : Artemis Giannakopoulou [Royaume-Uni] ; John F C. Steele [Royaume-Uni] ; Maria Eugenia Segretin [Argentine] ; Tolga O. Bozkurt [Royaume-Uni] ; Ji Zhou [Royaume-Uni] ; Silke Robatzek [Royaume-Uni] ; Mark J. Banfield [Royaume-Uni] ; Marina Pais [Royaume-Uni] ; Sophien Kamoun [Royaume-Uni]Source :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2015.
Descripteurs français
- KwdFr :
- Données de séquences moléculaires (MeSH), Fusarium (immunologie), Fusarium (pathogénicité), Lycopersicon esculentum (immunologie), Lycopersicon esculentum (microbiologie), Phytophthora infestans (immunologie), Phytophthora infestans (pathogénicité), Récepteurs immunologiques (composition chimique), Récepteurs immunologiques (immunologie), Séquence d'acides aminés (MeSH).
- MESH :
- composition chimique : Récepteurs immunologiques.
- immunologie : Fusarium, Lycopersicon esculentum, Phytophthora infestans, Récepteurs immunologiques.
- microbiologie : Lycopersicon esculentum.
- pathogénicité : Fusarium, Phytophthora infestans.
- Données de séquences moléculaires, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Fusarium (immunology), Fusarium (pathogenicity), Lycopersicon esculentum (immunology), Lycopersicon esculentum (microbiology), Molecular Sequence Data (MeSH), Phytophthora infestans (immunology), Phytophthora infestans (pathogenicity), Receptors, Immunologic (chemistry), Receptors, Immunologic (immunology).
- MESH :
- chemical , chemistry : Receptors, Immunologic.
- immunology : Fusarium, Lycopersicon esculentum, Phytophthora infestans, Receptors, Immunologic.
- microbiology : Lycopersicon esculentum.
- pathogenicity : Fusarium, Phytophthora infestans.
- Amino Acid Sequence, Molecular Sequence Data.
Abstract
Plants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins, to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that expand the response of the potato immune receptor R3a to AVR3a(EM), a stealthy effector from the late blight oomycete pathogen Phytophthora infestans. I2, another NLR that mediates resistance to the will-causing fungus Fusarium oxysporum f. sp. lycopersici, is the tomato ortholog of R3a. We transferred previously identified R3a mutations to I2 to assess the degree to which the resulting I2 mutants have an altered response. We discovered that wild-type I2 protein responds weakly to AVR3a. One mutant in the N-terminal coiled-coil domain, I2(I141N), appeared sensitized and displayed markedly increased response to AVR3a. Remarkably, I2(I141N) conferred partial resistance to P. infestans. Further, I2(I141N) has an expanded response spectrum to F. oxysporum f. sp. lycopersici effectors compared with the wild-type I2 protein. Our results suggest that synthetic immune receptors can be engineered to confer resistance to phylogenetically divergent pathogens and indicate that knowledge gathered for one NLR could be exploited to improve NLR from other plant species.
DOI: 10.1094/MPMI-07-15-0147-R
PubMed: 26367241
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Steele</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Segretin, Maria Eugenia" sort="Segretin, Maria Eugenia" uniqKey="Segretin M" first="Maria Eugenia" last="Segretin">Maria Eugenia Segretin</name><affiliation wicri:level="1"><nlm:affiliation>3 INGEBI-CONICET, Ciudad Autónoma de Buenos Aires, C1428ADN, Argentina;</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>3 INGEBI-CONICET, Ciudad Autónoma de Buenos Aires, C1428ADN</wicri:regionArea><wicri:noRegion>C1428ADN</wicri:noRegion></affiliation></author><author><name sortKey="Bozkurt, Tolga O" sort="Bozkurt, Tolga O" uniqKey="Bozkurt T" first="Tolga O" last="Bozkurt">Tolga O. Bozkurt</name><affiliation wicri:level="1"><nlm:affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation><affiliation><nlm:affiliation>4 Imperial College, Faculty of Natural Sciences, Department of Life Sciences, South Kensington Campus, London SW7 2AZ, United Kingdom; and.</nlm:affiliation><wicri:noCountry code="subField">United Kingdom; and</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Ji" sort="Zhou, Ji" uniqKey="Zhou J" first="Ji" last="Zhou">Ji Zhou</name><affiliation wicri:level="1"><nlm:affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>5 The Genome Analysis Centre, Norwich Research Park, NR4 7UH Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>5 The Genome Analysis Centre, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Robatzek, Silke" sort="Robatzek, Silke" uniqKey="Robatzek S" first="Silke" last="Robatzek">Silke Robatzek</name><affiliation wicri:level="1"><nlm:affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Banfield, Mark J" sort="Banfield, Mark J" uniqKey="Banfield M" first="Mark J" last="Banfield">Mark J. Banfield</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Pais, Marina" sort="Pais, Marina" uniqKey="Pais M" first="Marina" last="Pais">Marina Pais</name><affiliation wicri:level="1"><nlm:affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Kamoun, Sophien" sort="Kamoun, Sophien" uniqKey="Kamoun S" first="Sophien" last="Kamoun">Sophien Kamoun</name><affiliation wicri:level="1"><nlm:affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich</wicri:regionArea><wicri:noRegion>NR4 7UH Norwich</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular plant-microbe interactions : MPMI</title><idno type="ISSN">0894-0282</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Fusarium (immunology)</term><term>Fusarium (pathogenicity)</term><term>Lycopersicon esculentum (immunology)</term><term>Lycopersicon esculentum (microbiology)</term><term>Molecular Sequence Data (MeSH)</term><term>Phytophthora infestans (immunology)</term><term>Phytophthora infestans (pathogenicity)</term><term>Receptors, Immunologic (chemistry)</term><term>Receptors, Immunologic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Données de séquences moléculaires (MeSH)</term><term>Fusarium (immunologie)</term><term>Fusarium (pathogénicité)</term><term>Lycopersicon esculentum (immunologie)</term><term>Lycopersicon esculentum (microbiologie)</term><term>Phytophthora infestans (immunologie)</term><term>Phytophthora infestans (pathogénicité)</term><term>Récepteurs immunologiques (composition chimique)</term><term>Récepteurs immunologiques (immunologie)</term><term>Séquence d'acides aminés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Receptors, Immunologic</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Récepteurs immunologiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Fusarium</term><term>Lycopersicon esculentum</term><term>Phytophthora infestans</term><term>Récepteurs immunologiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Fusarium</term><term>Lycopersicon esculentum</term><term>Phytophthora infestans</term><term>Receptors, Immunologic</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Lycopersicon esculentum</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Lycopersicon esculentum</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Fusarium</term><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Fusarium</term><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins, to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that expand the response of the potato immune receptor R3a to AVR3a(EM), a stealthy effector from the late blight oomycete pathogen Phytophthora infestans. I2, another NLR that mediates resistance to the will-causing fungus Fusarium oxysporum f. sp. lycopersici, is the tomato ortholog of R3a. We transferred previously identified R3a mutations to I2 to assess the degree to which the resulting I2 mutants have an altered response. We discovered that wild-type I2 protein responds weakly to AVR3a. One mutant in the N-terminal coiled-coil domain, I2(I141N), appeared sensitized and displayed markedly increased response to AVR3a. Remarkably, I2(I141N) conferred partial resistance to P. infestans. Further, I2(I141N) has an expanded response spectrum to F. oxysporum f. sp. lycopersici effectors compared with the wild-type I2 protein. Our results suggest that synthetic immune receptors can be engineered to confer resistance to phylogenetically divergent pathogens and indicate that knowledge gathered for one NLR could be exploited to improve NLR from other plant species.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26367241</PMID><DateCompleted><Year>2016</Year><Month>02</Month><Day>09</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>Tomato I2 Immune Receptor Can Be Engineered to Confer Partial Resistance to the Oomycete Phytophthora infestans in Addition to the Fungus Fusarium oxysporum.</ArticleTitle><Pagination><MedlinePgn>1316-29</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/MPMI-07-15-0147-R</ELocationID><Abstract><AbstractText>Plants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins, to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that expand the response of the potato immune receptor R3a to AVR3a(EM), a stealthy effector from the late blight oomycete pathogen Phytophthora infestans. I2, another NLR that mediates resistance to the will-causing fungus Fusarium oxysporum f. sp. lycopersici, is the tomato ortholog of R3a. We transferred previously identified R3a mutations to I2 to assess the degree to which the resulting I2 mutants have an altered response. We discovered that wild-type I2 protein responds weakly to AVR3a. One mutant in the N-terminal coiled-coil domain, I2(I141N), appeared sensitized and displayed markedly increased response to AVR3a. Remarkably, I2(I141N) conferred partial resistance to P. infestans. Further, I2(I141N) has an expanded response spectrum to F. oxysporum f. sp. lycopersici effectors compared with the wild-type I2 protein. Our results suggest that synthetic immune receptors can be engineered to confer resistance to phylogenetically divergent pathogens and indicate that knowledge gathered for one NLR could be exploited to improve NLR from other plant species.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Giannakopoulou</LastName><ForeName>Artemis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steele</LastName><ForeName>John F C</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segretin</LastName><ForeName>Maria Eugenia</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>3 INGEBI-CONICET, Ciudad Autónoma de Buenos Aires, C1428ADN, Argentina;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozkurt</LastName><ForeName>Tolga O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>4 Imperial College, Faculty of Natural Sciences, Department of Life Sciences, South Kensington Campus, London SW7 2AZ, United Kingdom; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Ji</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>5 The Genome Analysis Centre, Norwich Research Park, NR4 7UH Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robatzek</LastName><ForeName>Silke</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banfield</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>2 Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pais</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamoun</LastName><ForeName>Sophien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1 The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, United Kingdom;</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BBS/E/J/000C0624</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011971">Receptors, Immunologic</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005670" MajorTopicYN="N">Fusarium</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018551" MajorTopicYN="N">Lycopersicon esculentum</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055750" MajorTopicYN="N">Phytophthora infestans</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011971" MajorTopicYN="N">Receptors, Immunologic</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26367241</ArticleId><ArticleId IdType="doi">10.1094/MPMI-07-15-0147-R</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Argentine</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Giannakopoulou, Artemis" sort="Giannakopoulou, Artemis" uniqKey="Giannakopoulou A" first="Artemis" last="Giannakopoulou">Artemis Giannakopoulou</name></noRegion><name sortKey="Banfield, Mark J" sort="Banfield, Mark J" uniqKey="Banfield M" first="Mark J" last="Banfield">Mark J. Banfield</name><name sortKey="Bozkurt, Tolga O" sort="Bozkurt, Tolga O" uniqKey="Bozkurt T" first="Tolga O" last="Bozkurt">Tolga O. Bozkurt</name><name sortKey="Kamoun, Sophien" sort="Kamoun, Sophien" uniqKey="Kamoun S" first="Sophien" last="Kamoun">Sophien Kamoun</name><name sortKey="Pais, Marina" sort="Pais, Marina" uniqKey="Pais M" first="Marina" last="Pais">Marina Pais</name><name sortKey="Robatzek, Silke" sort="Robatzek, Silke" uniqKey="Robatzek S" first="Silke" last="Robatzek">Silke Robatzek</name><name sortKey="Steele, John F C" sort="Steele, John F C" uniqKey="Steele J" first="John F C" last="Steele">John F C. Steele</name><name sortKey="Zhou, Ji" sort="Zhou, Ji" uniqKey="Zhou J" first="Ji" last="Zhou">Ji Zhou</name><name sortKey="Zhou, Ji" sort="Zhou, Ji" uniqKey="Zhou J" first="Ji" last="Zhou">Ji Zhou</name></country><country name="Argentine"><noRegion><name sortKey="Segretin, Maria Eugenia" sort="Segretin, Maria Eugenia" uniqKey="Segretin M" first="Maria Eugenia" last="Segretin">Maria Eugenia Segretin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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